It seems that InstallShield lost the path of your prerequisites.
A clean way to do it is to go to “Redistributables” section of your installshild project (inside your visual studio “setup” project)
( 2- Specify Application Data / Redistributables ).
Normally Prerequisites you need should me marked “Needs to be downloaded”.
Just download them with a Right Click directly on the table entry, and your problem will be fix .
I got the same problem when I opened a installshield project on a brand new machine.
I had re-installed InstallShield of course, but Prerequisites were of course absent and needed to be donwloaded again.
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Uncheck Microsoft.Net Framework 4.5 then recheck it, it will tell you it’s not installed on the machine and will redownload a good copy!
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